Current Issue


Liraglutide had best outcomes in trial of second-line therapies added to metformin

Patients randomized to liraglutide had a 60.3% risk of reaching a composite outcome of glycemic deterioration, weight gain, or hypoglycemia compared with 81.4% on glimepiride, 71.9% on glargine, and 69.6% on sitagliptin.

Certain beverages associated with CVD risk in type 2 diabetes patients

For each increase of one unit per day in consumption of sugar-sweetened beverages, artificially sweetened beverages, and natural juices, risk for cardiovascular disease (CVD) was 11%, 9%, and 16% higher, respectively, a study of U.K. data found. Coffee and tea were not associated with CVD.

SGLT-2 inhibitors associated with lower risk of kidney stones vs. other new diabetes drugs

Possible mechanisms to explain the association include increased urinary citrate excretion, increased urinary bicarbonate excretion that raises urine pH, or anti-inflammatory effects.

MKSAP quiz: Hypoglycemia evaluation

This month's quiz asks readers to evaluate a patient without diabetes who has recurrent hypoglycemia episodes.

Spotlight on comparisons within diabetes drug classes

One review found tirzepatide to have more effect on glycemic outcomes than other glucagon-like peptide-1 receptor agonists, while another showed several sodium-glucose cotransporter-2 inhibitors to have similar effects on cardiovascular outcomes.

In T2DM with obesity, time-restricted eating increased weight loss and reduced HbA1c level at 6 mo

The small trial comparing time-restricted eating and calorie restriction with control was adequately powered to inform clinical practice, but larger trials with longer follow-up should be done to confirm the results, an ACP Journal Club commentary said.

Shifts in insulin use

Changes in technology and drug prices have affected how physicians manage patients with insulin-treated diabetes.

Acute oxalate nephropathy in a patient with diabetes

A recent case report described a woman with long-standing diabetes who developed acute oxalate nephropathy during a hospitalization for diabetic ketoacidosis.