Search results for "Highlights"
SGLT-2 inhibitors linked to more diabetic ketoacidosis vs. DPP-4 inhibitors or sulfonylureas
A retrospective study found that new users of sodium-glucose cotransporter-2 (SGLT-2) inhibitors developed diabetic ketoacidosis at a rate of about 6 per 1,000 person-years, compared to 4.3 or 4.5 per 1,000 person-years with dipeptidyl peptidase-4 (DPP-4) inhibitors or sulfonylureas, respectively.
https://diabetes.acponline.org/archives/2022/03/11/1.htm
11 Mar 2022
Obesity increasing in type 1 diabetes, associated with higher risk for chronic kidney disease
Obesity in type 1 diabetes rose from 2004 to 2018, and patients with type 1 had a higher adjusted prevalence of low estimated glomerular filtration rate and albuminuria than those with type 2, an analysis of one health system found.
https://diabetes.acponline.org/archives/2022/02/11/3.htm
11 Feb 2022
Nearly one-third of patients were nonadherent to newly prescribed SGLT-2 inhibitors, GLP-1 receptor agonists
Factors associated with not filling a new prescription for a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist included older age, Black race, male sex, certain comorbid conditions, and having a primary care clinician prescribe the drug, a study found.
https://diabetes.acponline.org/archives/2022/02/11/2.htm
11 Feb 2022
Tirzepatide may improve glycemic control when added to insulin glargine in type 2 diabetes
An industry-sponsored phase 3 trial found statistically significant improvements in HbA1c level among patients with type 2 diabetes who had inadequate glycemic control on insulin glargine and were randomly assigned to subcutaneous tirzepatide once weekly versus placebo.
https://diabetes.acponline.org/archives/2022/02/11/1.htm
11 Feb 2022
Metformin use during pregnancy not associated with adverse outcomes in children
A industry-conducted cohort study in Finland found that childhood obesity, hypoglycemia, hyperglycemia, diabetes, and challenges in motor-social development did not appear to be associated with in utero exposure to metformin or metformin and insulin versus insulin alone.
https://diabetes.acponline.org/archives/2022/01/14/3.htm
14 Jan 2022
Association of inflammation with mortality in COVID-19 didn't differ by diabetes status
A single-center, case-control study of patients who were hospitalized with COVID-19 found a link between elevated levels of IL-6, IL-8, and interferon-γ-induced protein 10 and mortality risk, regardless of whether patients had type 2 diabetes.
https://diabetes.acponline.org/archives/2022/01/14/2.htm
14 Jan 2022
Neurologists update guideline on treatment of painful diabetic neuropathy
The updated guideline from the American Academy of Neurology supports offering tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, and/or sodium channel blockers to reduce pain from diabetic neuropathy.
https://diabetes.acponline.org/archives/2022/01/14/1.htm
14 Jan 2022
Adults with diabetes more likely to report mental stress during the COVID-19 pandemic
An online survey of U.S. adults in mid-2020, most of whom were White women, found that those with diabetes were less likely to report resilience and more likely to experience depression than adults without diabetes.
https://diabetes.acponline.org/archives/2021/12/10/3.htm
10 Dec 2021
Study finds long-term reductions in cardiovascular risk factors with SGLT-2 inhibitors
While the meta-analysis also found durable reductions in macrovascular complications and mortality with sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus placebo, there were insufficient data comparing the drug class to other antihyperglycemic medications.
https://diabetes.acponline.org/archives/2021/12/10/2.htm
10 Dec 2021
Hospitalizations for diabetes complications fell, were replaced by other causes
An analysis of excess hospitalizations among people with diabetes in England from 2003 to 2018 found that diabetes caused fewer of their hospital stays, with respiratory disease and cancer becoming more predominant diagnoses.
https://diabetes.acponline.org/archives/2021/12/10/1.htm
10 Dec 2021